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Peptide record

TPDB40124

Neurotoxin Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB40124
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 10-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
VVGCPWQPWC
Physicochemical Analysis
C55H75N13O12S2
ARNDEHILKMFSTY
CPWV
1174.40
5.18
0
0
4
-0
-2.55
0.450
58.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
11125
947.29
3
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
0
E
1
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 2 Y: 0 V: 2
Chemical Descriptors
10
C55H75N13O12S2
1174.40
5.18
-0
-2.55
0.450
Evidence Records 3 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa). {ECO:0000250|UniProtKB:P0C248, ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903, ECO:0000250|UniProtKB:P83047}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus zeylanicus (Obese cone) (Puncticulis zeylanicus)
Neurotoxin Ion channel impairing toxin
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa)..
Contryphan-Ze (Z1187)
cone snail
O2 superfamily, Contryphan family
Evidence at protein level
Amidation D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17902199}.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa). {ECO:0000250|UniProtKB:P0C248, ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903, ECO:0000250|UniProtKB:P83047}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus betulinus (Beech cone)
Neurotoxin Ion channel impairing toxin
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa)..
Contryphan-Bt (B1187)
cone snail
O2 superfamily, Contryphan family
Evidence at protein level
Amidation D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17902199}.
Evidence 3 Activity

Activity

Neurotoxin
FUNCTION: Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa). {ECO:0000250|UniProtKB:P0C248, ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903, ECO:0000250|UniProtKB:P83047}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus figulinus (Fig cone)
Neurotoxin Ion channel impairing toxin
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa)..
Contryphan-Fia (Fi1187)
cone snail
O2 superfamily, Contryphan family
Evidence at protein level
Amidation D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17902199}.
Additional Detail Fields 7 fields
Amidation D-amino acid Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
O2 superfamily, Contryphan family
Contryphan-Ze (Z1187) Contryphan-Bt (B1187) Contryphan-Fia (Fi1187)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17902199}.
cone snail