Back to search

Peptide record

TPDB40070

Neurotoxin Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB40070
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
KDGYLVGSDGCKYSCLTRPG
Physicochemical Analysis
C90H143N25O30S2
ANEQHIMFW
G
2119.39
8.26
3
2
5
+1
2.73
-0.530
53.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
3105
146.50
7
Residue Composition
number
0
A
1
R
0
N
2
D
2
C
0
E
0
Q
4
G
0
H
0
I
2
L
2
K
0
M
0
F
1
P
2
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 2 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 2 K: 2 M: 0 F: 0 P: 1 S: 2 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
20
C90H143N25O30S2
2119.39
8.26
+1
2.73
-0.530
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus pachyurus (Colombian scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing..
Putative beta-neurotoxin
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16309982}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Putative beta-neurotoxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:16309982}.
scorpion