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Peptide record

TPDB39926

Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB39926
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
RCKTCSKGRCRPKPNCG
Physicochemical Analysis
C73H132N30O21S4
ADEQHILMFWYV
C
1894.28
10.33
6
0
0
+6
6.05
-1.424
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
250
13.20
7
Residue Composition
number
0
A
3
R
1
N
0
D
4
C
0
E
0
Q
2
G
0
H
0
I
0
L
3
K
0
M
0
F
2
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C73H132N30O21S4
1894.28
10.33
+6
6.05
-1.424
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Voltage-gated potassium channel inhibitor that is certainly used for prey capture (PubMed:30109357). It inhibits several potassium channels, but not all (Kv1.1/KCNA1 (IC(50)=353 nM), Kv1.2/KCNA2 (IC(50)=146 nM), Kv1.3/KCNA3 (IC(50)=3051 nM), Kv1.6/KCNA6 (IC(50)=191 nM), and Shaker IR (23% inhibition at 3 uM)) (PubMed:30109357). In vivo, injection of this toxin into amphipods results in impaired swimming followed by contractile paralysis (PubMed:30109357). {ECO:0000269|PubMed:30109357}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Actinia tenebrosa (Australian red waratah sea anemone)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Voltage-gated potassium channel inhibitor that is certainly used for prey capture (PubMed:30109357). It inhibits several potassium channels, but not all (Kv1.1/KCNA1 (IC(50)=353 nM), Kv1.2/KCNA2 (IC(50)=146 nM), Kv1.3/KCNA3 (IC(50)=3051 nM), Kv1.6/KCNA6 (IC(50)=191 nM), and Shaker IR (23% inhibition at 3 uM)) (PubMed:30109357).
Kappa-actitoxin-Ate1a (Ate1a)
sea anemone
Sea anemonne PHAB family
Evidence at protein level
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Reference proteome Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by tentacle. {ECO:0000269|PubMed:30109357}.
Additional Detail Fields 7 fields
3D-structure Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Potassium channel impairing toxin Reference proteome Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Sea anemonne PHAB family
Kappa-actitoxin-Ate1a (Ate1a)
TISSUE SPECIFICITY: Expressed by tentacle. {ECO:0000269|PubMed:30109357}.
sea anemone