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Peptide record

TPDB39921

Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB39921
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
IMYDCCSGSCSGYTGRC
Physicochemical Analysis
C70H108N20O26S5
ANEQHLKFPWV
C
1806.05
5.79
1
1
4
-0
-0.78
0.088
22.94
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
3230
178.84
10
Residue Composition
number
0
A
1
R
0
N
1
D
4
C
0
E
0
Q
3
G
0
H
1
I
0
L
0
K
1
M
0
F
0
P
3
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 4 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 0 K: 0 M: 1 F: 0 P: 0 S: 3 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
17
C70H108N20O26S5
1806.05
5.79
-0
-0.78
0.088
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. {ECO:0000250}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus stercusmuscarum (Fly-specked cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them..
Alpha-conotoxin-like Sm1.4
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Oxidation Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:22709442}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Oxidation Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin-like Sm1.4
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:22709442}.
cone snail