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Peptide record

TPDB39919

Neurotoxin Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB39919
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 9-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
RCPWDPWCN
Physicochemical Analysis
C52H69N15O13S2
AEQGHILKMFSTYV
CPW
1176.33
5.95
1
1
2
-0
-0.82
-1.278
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11125
945.74
3
Residue Composition
number
0
A
1
R
1
N
1
D
2
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 1 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
9
C52H69N15O13S2
1176.33
5.95
-0
-0.82
-1.278
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa). {ECO:0000250|UniProtKB:P0C248, ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903, ECO:0000250|UniProtKB:P83047}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus inscriptus (Engraved cone)
Neurotoxin Ion channel impairing toxin
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa)..
Contryphan-In1172
cone snail
O2 superfamily, Contryphan family
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:33732044}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
O2 superfamily, Contryphan family
Contryphan-In1172
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:33732044}.
cone snail