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Peptide record

TPDB39908

Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB39908
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
DCCPCPAGAVRCRFACC
Physicochemical Analysis
C69H111N23O20S6
NEQHILKMSTWY
C
1775.14
7.63
2
1
5
+1
0.75
0.665
34.71
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
375
21.13
6
Residue Composition
number
3
A
2
R
0
N
1
D
6
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 2 N: 0 D: 1 C: 6 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C69H111N23O20S6
1775.14
7.63
+1
0.75
0.665
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Elicits excitatory activity in two subsets of the mouse dorsal root ganglion neurons the medium diameter isolectin B4-expressing neurons and the small diameter CGRP-expressing neurons. Displays low inhibition of the human alpha-9-alpha-10 nAChR (IC(50)=10.2 uM). In vivo, intracranial injection into mice causes strong tremors and impaired locomotion for around 3 hours after administration. {ECO:0000269|PubMed:29090914}.

Target

nicotinic acetylcholine receptor (nAChR)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Unedogemmula bisaya (Sea snail) (Lophiotoma bisaya)
Neurotoxin
Elicits excitatory activity in two subsets of the mouse dorsal root ganglion neurons the medium diameter isolectin B4-expressing neurons and the small diameter CGRP-expressing neurons. Displays low inhibition of the human alpha-9-alpha-10 nAChR (IC(50)=10.2 uM).
Turripeptide ubi3a
other
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Hydroxylation Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:29090914}.
Additional Detail Fields 6 fields
Amidation Direct protein sequencing Disulfide bond Hydroxylation Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Turripeptide ubi3a
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:29090914}.
other