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Peptide record

TPDB39907

Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB39907
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
EGCCSNPPCRHNHPEVC
Physicochemical Analysis
C73H112N26O25S4
ADQILKMFTWY
C
1882.09
6.01
3
2
1
-1
8.21
-0.982
17.06
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
250
13.28
7
Residue Composition
number
0
A
1
R
2
N
0
D
4
C
2
E
0
Q
1
G
2
H
0
I
0
L
0
K
0
M
0
F
3
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 0 C: 4 E: 2 Q: 0 G: 1 H: 2 I: 0 L: 0 K: 0 M: 0 F: 0 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C73H112N26O25S4
1882.09
6.01
-1
8.21
-0.982
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. {ECO:0000250|UniProtKB:X1WB75}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus inscriptus (Engraved cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them..
Alpha-conotoxin In1907 (Alpha-conotoxin In1857) (Alpha-conotoxin In1874) (Alpha-conotoxin In1891)
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:33732044}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Pyrrolidone carboxylic acid Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin In1907 (Alpha-conotoxin In1857) (Alpha-conotoxin In1874) (Alpha-conotoxin In1891)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:33732044}.
cone snail