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Peptide record

TPDB39906

Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB39906
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
SGCCSNPACRVNNPNIC
Physicochemical Analysis
C66H110N24O24S4
DEQHLKMFTWY
NC
1751.99
7.84
1
0
3
+1
2.29
-0.188
45.88
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
250
14.27
10
Residue Composition
number
1
A
1
R
4
N
0
D
4
C
0
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
2
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 4 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C66H110N24O24S4
1751.99
7.84
+1
2.29
-0.188
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This globular toxin inhibits human alpha-7/CHRNA7 (IC(50)=0.3-10.1 nM), rat alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=10.3 nM) and rat alpha-3-alpha-5-beta-2/CHRNA3-CHRNB5-CHRNB2 (IC(50)=31.2 nM). {ECO:0000269|PubMed:23924607, ECO:0000269|PubMed:34753970}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus limpusi (Cone snail)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This globular toxin inhibits human alpha-7/CHRNA7 (IC(50)=0.3-10.1 nM), rat alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=10.3 nM) and rat alpha-3-alpha-5-beta-2/CHRNA3-CHRNB5-CHRNB2 (IC(50)=31.2 nM)..
Alpha-conotoxin LsIA
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:23924607}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin LsIA
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:23924607}.
cone snail