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Peptide record

TPDB39721

Neurotoxin Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB39721
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
CCQWPCSHGCIPCCY
Physicochemical Analysis
C70H99N19O19S6
ARNDELKMFTV
C
1703.03
6.74
1
0
3
-0
-1.96
0.413
26.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
7365
432.46
9
Residue Composition
number
0
A
0
R
0
N
0
D
6
C
0
E
1
Q
1
G
1
H
1
I
0
L
0
K
0
M
0
F
2
P
1
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 6 E: 0 Q: 1 G: 1 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 1 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
15
C70H99N19O19S6
1703.03
6.74
-0
-1.96
0.413
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Does not show any effect on voltage-gated sodium and potassium channels (10 uM of toxin tested), and on nicotinic acetylcholine receptors (5 uM of toxin tested) (PubMed:27801785). Does not show antibacterial activity on both Gram-negative and Gram-positive bacteria (PubMed:27801785). Intraperitoneal injection into fish provokes paralysis (By similarity). {ECO:0000250|UniProtKB:P0CH15, ECO:0000269|PubMed:27801785}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus asiaticus (Cone snail)
Neurotoxin
Does not show any effect on voltage-gated sodium and potassium channels (10 uM of toxin tested), and on nicotinic acetylcholine receptors (5 uM of toxin tested) (PubMed:27801785). Does not show antibacterial activity on both Gram-negative and Gram-positive bacteria (PubMed:27801785).
Conotoxin Asi3a
cone snail
Conotoxin M superfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:27801785}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Conotoxin M superfamily
Conotoxin Asi3a
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000269|PubMed:27801785}.
cone snail