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Peptide record

TPDB39684

Neurotoxin Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB39684
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
DYCCRRPTCIPIC
Physicochemical Analysis
C63H103N19O18S4
ANEQGHLKMFSWV
C
1542.87
7.84
2
1
3
+1
1.37
0.100
60.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
1740
112.78
6
Residue Composition
number
0
A
2
R
0
N
1
D
4
C
0
E
0
Q
0
G
0
H
2
I
0
L
0
K
0
M
0
F
2
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 1 C: 4 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C63H103N19O18S4
1542.87
7.84
+1
1.37
0.100
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Acts as an inhibitor of nicotinic acetylcholine receptors (nAChR) (PubMed:25466886). Specifically inhibits the alpha-7 nAChRs of D.melanogaster, and seems to have no inhibitory effect on vertebrate nAChR subtypes (PubMed:25466886). {ECO:0000269|PubMed:25466886}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus brunneus (Wood's brown cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Acts as an inhibitor of nicotinic acetylcholine receptors (nAChR) (PubMed:25466886). Specifically inhibits the alpha-7 nAChRs of D.melanogaster, and seems to have no inhibitory effect on vertebrate nAChR subtypes (PubMed:25466886)..
Alpha-conotoxin BruIB
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct (at protein level). {ECO:0000269|PubMed:25466886}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Direct protein sequencing Disulfide bond Hydroxylation Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin BruIB
TISSUE SPECIFICITY: Expressed by the venom duct (at protein level). {ECO:0000269|PubMed:25466886}.
cone snail