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Peptide record

TPDB39670

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB39670
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
EDCLGWFSRCSPKNDKCCPNYKCSSKDLWCKYKIW
Physicochemical Analysis
C187H277N49O52S6
AQHMTV
CK
4235.91
8.30
7
4
9
+3
3.30
-0.889
33.43
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
19855
468.73
14
Residue Composition
number
0
A
1
R
2
N
3
D
6
C
1
E
0
Q
1
G
0
H
1
I
2
L
6
K
0
M
1
F
2
P
4
S
0
T
3
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 2 D: 3 C: 6 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 6 M: 0 F: 1 P: 2 S: 4 T: 0 W: 3 Y: 2 V: 0
Chemical Descriptors
35
C187H277N49O52S6
4235.91
8.30
+3
3.30
-0.889
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Gating-modifier toxin that both inhibits the peak current of human Nav1.1/SCN1A, rat Nav1.2/SCN2A, human Nav1.6/SCN8A, and human Nav1.7/SCN9A and concurrently inhibits fast inactivation of human Nav1.1 and rat Nav1.3/SCN3A. The relative rank order potency for Nav modulation is Nav1.3 (inactivation EC(50)=45 nM) > Nav1.7 > Nav1.2 > Nav1.1 (inactivation) > Nav1.1 > Nav1.6 > Nav1.3 (IC(50)=8 uM). The DII and DIV S3-S4 loops of Nav channel voltage sensors are important for the interaction of this toxin with Nav channels but cannot account for its unique subtype selectivity. It is the variability of the S1-S2 loops between NaV channels which contributes substantially to the selectivity profile observed for this toxin, particularly with regards to fast inactivation. This toxin may bind the channel in the resting state (Probable). {ECO:0000269|PubMed:28428547, ECO:0000305|PubMed:28428547}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Psalmopoeus reduncus (Costa Rican orangemouth tarantula)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Gating-modifier toxin that both inhibits the peak current of human Nav1.1/SCN1A, rat Nav1.2/SCN2A, human Nav1.6/SCN8A, and human Nav1.7/SCN9A and concurrently inhibits fast inactivation of human Nav1.1 and rat Nav1.3/SCN3A. The relative rank order potency for Nav modulation is Nav1.3 (inactivation EC(50)=45 nM) > Nav1.7 > Nav1.2 > Nav1.1 (inactivation) > Nav1.1 > Nav1.6 > Nav1.3 (IC(50)=8 uM).
Beta/delta-theraphotoxin-Pre1a (Beta/delta-TRTX-Pre1a)
spider
Neurotoxin 10 (Hwtx-1) family
Evidence at protein level
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:28428547}.
Additional Detail Fields 7 fields
3D-structure Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family
Beta/delta-theraphotoxin-Pre1a (Beta/delta-TRTX-Pre1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:28428547}.
spider