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Peptide record

TPDB39665

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB39665
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
DDCLGFFKSCNPDNDKCCENYKCNRRDKWCKYVL
Physicochemical Analysis
C175H264N50O54S6
AQHIMT
C
4124.68
7.62
7
6
8
+1
8.53
-1.100
31.47
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
8855
214.68
13
Residue Composition
number
0
A
2
R
4
N
5
D
6
C
1
E
0
Q
1
G
0
H
0
I
2
L
5
K
0
M
2
F
1
P
1
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 4 D: 5 C: 6 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 5 M: 0 F: 2 P: 1 S: 1 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
34
C175H264N50O54S6
4124.68
7.62
+1
8.53
-1.100
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Voltage-gated sodium channel Nav1.7/SCN9A inhibitor. {ECO:0000269|PubMed:25754331}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Chromatopelma cyaneopubescens (Greenbottle blue tarantula) (Eurypelma cyaneopubescens)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Voltage-gated sodium channel Nav1.7/SCN9A inhibitor..
Mu-theraphotoxin-CCy1b (Mu-TRTX-CCy1b)
spider
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 22 (Htx-4) subfamily
Mu-theraphotoxin-CCy1b (Mu-TRTX-CCy1b)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
spider