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Peptide record

TPDB39664

Neurotoxin Toxicity standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB39664
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 34-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
DDCLGIFKSCNPDNDKCCESYKCSRRDKWCKYVL
Physicochemical Analysis
C170H264N48O54S6
AQHMT
C
4036.62
7.62
7
6
8
+1
8.77
-0.891
42.94
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
8855
219.37
13
Residue Composition
number
0
A
2
R
2
N
5
D
6
C
1
E
0
Q
1
G
0
H
1
I
2
L
5
K
0
M
1
F
1
P
3
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 5 C: 6 E: 1 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 5 M: 0 F: 1 P: 1 S: 3 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
34
C170H264N48O54S6
4036.62
7.62
+1
8.77
-0.891
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Voltage-gated sodium channel Nav1.7/SCN9A inhibitor. {ECO:0000269|PubMed:25754331}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Chromatopelma cyaneopubescens (Greenbottle blue tarantula) (Eurypelma cyaneopubescens)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Voltage-gated sodium channel Nav1.7/SCN9A inhibitor..
Mu-theraphotoxin-CCy1a (Mu-TRTX-CCy1a)
spider
Neurotoxin 10 (Hwtx-1) family, 14 (Hntx-1) subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 10 (Hwtx-1) family, 14 (Hntx-1) subfamily
Mu-theraphotoxin-CCy1a (Mu-TRTX-CCy1a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:25754331}.
spider