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Peptide record

TPDB39651

Neurotoxin Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB39651
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
LTCLNCPEMFCGKFQICRNGEKICFKKLHQRRP
Physicochemical Analysis
C171H278N52O43S6
ADSWYV
C
3942.77
9.28
8
2
9
+5
7.33
-0.448
59.09
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
250
6.34
10
Residue Composition
number
0
A
3
R
2
N
0
D
5
C
2
E
2
Q
2
G
1
H
2
I
3
L
4
K
1
M
3
F
2
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 2 D: 0 C: 5 E: 2 Q: 2 G: 2 H: 1 I: 2 L: 3 K: 4 M: 1 F: 3 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
33
C171H278N52O43S6
3942.77
9.28
+5
7.33
-0.448
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Possible voltage-gated potassium channel (Kv) blocker. Decreases amplitude of compound action potential and conduction velocity in toad sciatic nerve. Has only mild anticoagulant activity even at a concentration of 5ug/ml. Shows no cytotoxicity towards human cell lines. {ECO:0000269|PubMed:26293154}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Naja kaouthia (Monocled cobra) (Naja siamensis)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Possible voltage-gated potassium channel (Kv) blocker. Decreases amplitude of compound action potential and conduction velocity in toad sciatic nerve.
Neurotoxin Nk-3FTx
snake
Three-finger toxin family, Ancestral subfamily, Orphan group II sub-subfamily
Evidence at protein level
Blood coagulation cascade inhibiting toxin Direct protein sequencing Disulfide bond Hemostasis impairing toxin Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26293154}.
Additional Detail Fields 7 fields
Blood coagulation cascade inhibiting toxin Direct protein sequencing Disulfide bond Hemostasis impairing toxin Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Three-finger toxin family, Ancestral subfamily, Orphan group II sub-subfamily
Neurotoxin Nk-3FTx
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26293154}.
snake