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Peptide record

TPDB39592

Neurotoxin Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB39592
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 10-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
ESECPWHPWC
Physicochemical Analysis
C57H72N14O16S2
ARNDQGILKMFTYV
CEPW
1273.40
4.25
1
2
2
-2
1.85
-1.100
0.00
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
11125
873.64
3
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
2
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
0
F
2
P
1
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 2 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 2 S: 1 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
10
C57H72N14O16S2
1273.40
4.25
-2
1.85
-1.100
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa). {ECO:0000250|UniProtKB:P0C248, ECO:0000250|UniProtKB:P0C250, ECO:0000250|UniProtKB:P62903, ECO:0000250|UniProtKB:P83047}.

Target

voltage-gated potassium channel (Kv) voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus araneosus (Cobweb cone)
Neurotoxin Ion channel impairing toxin
Its target is unknown, but this toxin may modulate voltage-activated calcium channels (Cav) or calcium-dependent potassium channels (KCa)..
Contryphan-Ar4 (Ar1313)
cone snail
O2 superfamily, Contryphan family
Evidence at protein level
Amidation D-amino acid Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:28152596}.
Additional Detail Fields 7 fields
Amidation D-amino acid Direct protein sequencing Disulfide bond Gamma-carboxyglutamic acid Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Ion channel impairing toxin
Evidence at protein level
O2 superfamily, Contryphan family
Contryphan-Ar4 (Ar1313)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:28152596}.
cone snail