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Peptide record

TPDB39575

Neurotoxin Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB39575
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
KDGYLVGNDGCKYSCNTYPK
Physicochemical Analysis
C96H145N25O32S2
AREQHIMFW
GKY
2225.48
8.25
3
2
5
+1
3.23
-1.045
34.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
4595
206.47
9
Residue Composition
number
0
A
0
R
2
N
2
D
2
C
0
E
0
Q
3
G
0
H
0
I
1
L
3
K
0
M
0
F
1
P
1
S
1
T
0
W
3
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 2 C: 2 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 3 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 3 V: 1
Chemical Descriptors
20
C96H145N25O32S2
2225.48
8.25
+1
3.23
-1.045
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. {ECO:0000250}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus pachyurus (Colombian scorpion)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing..
Toxin TpF21-Cocle
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:29196122}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
Toxin TpF21-Cocle
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:29196122}.
scorpion