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Peptide record

TPDB39548

Neurotoxin Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB39548
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
GAKERNNAEAVRERLEEI
Physicochemical Analysis
C85H146N30O31
DCQHMFPSTWY
E
2084.28
4.85
4
5
6
-1
13.06
-1.356
76.11
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
3
A
3
R
2
N
0
D
0
C
5
E
0
Q
1
G
0
H
1
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 3 N: 2 D: 0 C: 0 E: 5 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C85H146N30O31
2084.28
4.85
-1
13.06
-1.356
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. {ECO:0000250}.

Target

glutamate receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus gloriamaris (Glory-of-the-Sea cone)
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors..
Conantokin-Gm (Con-Gm)
cone snail
Evidence at protein level
Gamma-carboxyglutamic acid Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
Additional Detail Fields 6 fields
Gamma-carboxyglutamic acid Ion channel impairing toxin Ionotropic glutamate receptor inhibitor Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Ion channel impairing toxin Ionotropic glutamate receptor inhibitor
Evidence at protein level
Conantokin-Gm (Con-Gm)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
cone snail