Back to search

Peptide record

TPDB39530

Neurotoxin Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB39530
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
SCGYPCSHCGIPGCYPG
Physicochemical Analysis
C71H101N19O22S4
ARNDEQLKMFTWV
CG
1700.94
6.84
1
0
3
-0
-0.54
0.041
22.94
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
3230
189.90
8
Residue Composition
number
0
A
0
R
0
N
0
D
4
C
0
E
0
Q
4
G
1
H
1
I
0
L
0
K
0
M
0
F
3
P
2
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 4 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 3 S: 2 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
17
C71H101N19O22S4
1700.94
6.84
-0
-0.54
0.041
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: May have neurotoxic activities (Probable). Does not show any effect on voltage-gated potassium channels (10 uM of toxin tested), and on nicotinic acetylcholine receptors (5 uM of toxin tested) (PubMed:27801785). Does not show antibacterial activity on both Gram-negative and Gram-positive bacteria (PubMed:27801785). {ECO:0000269|PubMed:27801785, ECO:0000305}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus asiaticus (Cone snail)
Neurotoxin
May have neurotoxic activities (Probable). Does not show any effect on voltage-gated potassium channels (10 uM of toxin tested), and on nicotinic acetylcholine receptors (5 uM of toxin tested) (PubMed:27801785).
Conotoxin Asi14a
cone snail
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:27801785}.
Additional Detail Fields 6 fields
Amidation Direct protein sequencing Disulfide bond Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Conotoxin Asi14a
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:27801785}.
cone snail