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Peptide record

TPDB39492

Neurotoxin Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB39492
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
SVDFDSESPRKPEIQ
Physicochemical Analysis
C74H116N20O28
ANCGHLMTWY
S
1733.85
4.06
2
4
3
-2
8.80
-1.333
45.33
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
0
A
1
R
0
N
2
D
0
C
2
E
1
Q
0
G
0
H
1
I
0
L
1
K
0
M
1
F
2
P
3
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 0 E: 2 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 2 S: 3 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
15
C74H116N20O28
1733.85
4.06
-2
8.80
-1.333
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Weakly blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction. May target voltage-gated calcium channels on smooth muscle (By similarity). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bothrops cotiara (Cotiara) (Rhinocerophis cotiara)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Weakly blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction. May target voltage-gated calcium channels on smooth muscle (By similarity)..
Cysteine-rich venom protein Bco13
snake
CRISP family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Weakly blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction. May target voltage-gated calcium channels on smooth muscle (By similarity). {ECO:0000250}.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Bothrops fonsecai (Fonseca's lancehead) (Rhinocerophis fonsecai)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Weakly blocks contraction of smooth muscle elicited by high potassium-induced depolarization, but does not block caffeine-stimulated contraction. May target voltage-gated calcium channels on smooth muscle (By similarity)..
Cysteine-rich venom protein Bfon12 (CRVP) (Cysteine-rich secretory protein) (CRISP)
snake
CRISP family
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Evidence at protein level
CRISP family
Cysteine-rich venom protein Bco13 Cysteine-rich venom protein Bfon12 (CRVP) (Cysteine-rich secretory protein) (CRISP)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake