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Peptide record

TPDB39489

Neurotoxin Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB39489
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 ToxinPred 3.0
standard
No
A 15-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and ToxinPred 3.0, with an available 3D structural model.
Sequence
KRKCGLCKYRCCSGG
Physicochemical Analysis
C66H116N24O18S4
ANDEQHIMFPTWV
C
1662.04
9.68
5
0
2
+5
2.29
-0.680
26.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1740
104.69
6
Residue Composition
number
0
A
2
R
0
N
0
D
4
C
0
E
0
Q
3
G
0
H
0
I
1
L
3
K
0
M
0
F
0
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 3 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
15
C66H116N24O18S4
1662.04
9.68
+5
2.29
-0.680
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: May block voltage-gated potassium channels (Kv). {ECO:0000305}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus stigmurus (Brazilian scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
May block voltage-gated potassium channels (Kv)..
Peptide 2900 (Potassium channel toxin alpha-KTx)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17270501}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family
Peptide 2900 (Potassium channel toxin alpha-KTx)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17270501}.
scorpion