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Peptide record

TPDB39377

Neurotoxin Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB39377
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 45-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
YKRCHKKGGHCFPKTVICLPPSSDFGKMDCRWKWKCCKKGSVNNA
Physicochemical Analysis
C227H356N68O57S7
EQ
K
5174.17
9.97
13
2
11
+9
8.20
-0.802
32.44
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
12865
248.64
13
Residue Composition
number
1
A
2
R
2
N
2
D
6
C
0
E
0
Q
4
G
2
H
1
I
1
L
9
K
1
M
2
F
3
P
3
S
1
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 2 D: 2 C: 6 E: 0 Q: 0 G: 4 H: 2 I: 1 L: 1 K: 9 M: 1 F: 2 P: 3 S: 3 T: 1 W: 2 Y: 1 V: 2
Chemical Descriptors
45
C227H356N68O57S7
5174.17
9.97
+9
8.20
-0.802
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism. {ECO:0000250|UniProtKB:Q9PWF3}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Crotalus viridis viridis (Prairie rattlesnake)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor.
Myotoxin-3
snake
Crotamine-myotoxin family
Evidence at protein level
Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Myotoxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2253781}.
Additional Detail Fields 7 fields
Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Myotoxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Crotamine-myotoxin family
Myotoxin-3
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:2253781}.
snake