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Peptide record

TPDB39369

Neurotoxin Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB39369
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 42-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
YKRCHIKGGHCFPKEKLICIPPSSDIGKMDCPWKRKCCKKRS
Physicochemical Analysis
C214H351N65O53S7
ANQTV
K
4906.96
9.96
14
3
9
+9
12.57
-0.862
46.43
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
7365
150.09
10
Residue Composition
number
0
A
3
R
0
N
2
D
6
C
1
E
0
Q
3
G
2
H
4
I
1
L
9
K
1
M
1
F
4
P
3
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 2 C: 6 E: 1 Q: 0 G: 3 H: 2 I: 4 L: 1 K: 9 M: 1 F: 1 P: 4 S: 3 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
42
C214H351N65O53S7
4906.96
9.96
+9
12.57
-0.862
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, and hind limb paralysis (By similarity). It also induces potent blockade of neuromuscular transmission in young chicken biventer cervicis preparation and potent myotoxic effect. In vivo, induces myonecrosis, upon intramuscular or subcutaneous injections into mice (PubMed:17828447). {ECO:0000250|UniProtKB:Q9PWF3, ECO:0000269|PubMed:17828447}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Crotalus durissus cumanensis (South American rattlesnake)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor.
Crotamine-IV-2
snake
Crotamine-myotoxin family
Evidence at protein level
Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Myotoxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17828447}.
Additional Detail Fields 7 fields
Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Myotoxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Crotamine-myotoxin family
Crotamine-IV-2
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17828447}.
snake