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Peptide record

TPDB39362

Neurotoxin Toxicity standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB39362
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 42-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
YKQCHKKGGHCFPKEKICIPPSSDLGKMDCRWKWKCCKKGSG
Physicochemical Analysis
C211H334N62O54S7
ANTV
K
4827.78
9.72
13
3
8
+8
10.86
-1.040
27.86
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
12865
266.48
11
Residue Composition
number
0
A
1
R
0
N
2
D
6
C
1
E
1
Q
5
G
2
H
2
I
1
L
10
K
1
M
1
F
3
P
3
S
0
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 6 E: 1 Q: 1 G: 5 H: 2 I: 2 L: 1 K: 10 M: 1 F: 1 P: 3 S: 3 T: 0 W: 2 Y: 1 V: 0
Chemical Descriptors
42
C211H334N62O54S7
4827.78
9.72
+8
10.86
-1.040
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism (By similarity). It also binds to sarcoplasmic reticulum calcium-ATPase (PubMed:1329655). {ECO:0000250|UniProtKB:Q9PWF3, ECO:0000269|PubMed:1329655}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Crotalus viridis viridis (Prairie rattlesnake)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor.
Myotoxin-A (Myotoxin-1)
snake
Crotamine-myotoxin family
Evidence at protein level
Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Myotoxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:570412}.
Additional Detail Fields 7 fields
Antimicrobial Direct protein sequencing Disulfide bond Ion channel impairing toxin Myotoxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Crotamine-myotoxin family
Myotoxin-A (Myotoxin-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:570412}.
snake