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Peptide record

TPDB39312

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB39312
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
YCQKWMWTCDSKRKCCEDMVCQLWCKKRL
Physicochemical Analysis
C159H249N45O41S8
ANGHIFP
C
3703.48
8.58
7
3
9
+4
3.04
-0.721
36.90
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
18365
495.88
11
Residue Composition
number
0
A
2
R
0
N
2
D
6
C
1
E
2
Q
0
G
0
H
0
I
2
L
5
K
2
M
0
F
0
P
1
S
1
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 2 C: 6 E: 1 Q: 2 G: 0 H: 0 I: 0 L: 2 K: 5 M: 2 F: 0 P: 0 S: 1 T: 1 W: 3 Y: 1 V: 1
Chemical Descriptors
29
C159H249N45O41S8
3703.48
8.58
+4
3.04
-0.721
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits voltage-gated sodium channels Nav1.1/SCN1A (IC(50)=630 nM), Nav1.2/SCN2A (IC(50)=230 nM), Nav1.3/SCN3A (IC(50)=770 nM), Nav1.4/SCN4A (IC(50)=1290 nM), Nav1.6/SCN8A (IC(50)=630 nM), Nav1.7/SCN9A (IC(50)=15.3-1000 nM) and potassium channels Kv11.1/KCNH2 (IC(50)=4.2 uM). {ECO:0000269|PubMed:17418351, ECO:0000269|PubMed:19955179, ECO:0000269|PubMed:30661758, ECO:0000269|PubMed:31234412}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits voltage-gated sodium channels Nav1.1/SCN1A (IC(50)=630 nM), Nav1.2/SCN2A (IC(50)=230 nM), Nav1.3/SCN3A (IC(50)=770 nM), Nav1.4/SCN4A (IC(50)=1290 nM), Nav1.6/SCN8A (IC(50)=630 nM), Nav1.7/SCN9A (IC(50)=15.3-1000 nM) and potassium channels Kv11.1/KCNH2 (IC(50)=4.2 uM)..
Beta-theraphotoxin-Gr1a (Beta-TRTX-Gr1a) (GrTx1)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17418351}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 30 (phrixotoxin) family
Beta-theraphotoxin-Gr1a (Beta-TRTX-Gr1a) (GrTx1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:17418351}.
spider