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Peptide record

TPDB39304

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB39304
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
YCQKWMWTCDEERKCCEGLVCRLWCKKKIEEG
Physicochemical Analysis
C172H267N47O48S7
ANHFPS
C
3985.72
7.62
7
6
9
+1
9.12
-0.791
45.62
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
18365
460.77
9
Residue Composition
number
0
A
2
R
0
N
1
D
6
C
5
E
1
Q
2
G
0
H
1
I
2
L
5
K
1
M
0
F
0
P
0
S
1
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 1 C: 6 E: 5 Q: 1 G: 2 H: 0 I: 1 L: 2 K: 5 M: 1 F: 0 P: 0 S: 0 T: 1 W: 3 Y: 1 V: 1
Chemical Descriptors
32
C172H267N47O48S7
3985.72
7.62
+1
9.12
-0.791
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds the voltage-sensor domain of the potassium channel KvAP (from the archaeon Aeropyrum pernix) and affects channel gating. {ECO:0000269|PubMed:15287735}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Binds the voltage-sensor domain of the potassium channel KvAP (from the archaeon Aeropyrum pernix) and affects channel gating..
Kappa-theraphotoxin-Gr2b (Kappa-TRTX-Gr2b) (Voltage sensor toxin 2) (VSTX2)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15287735}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Neurotoxin 30 (phrixotoxin) family
Kappa-theraphotoxin-Gr2b (Kappa-TRTX-Gr2b) (Voltage sensor toxin 2) (VSTX2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15287735}.
spider