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Peptide record

TPDB39301

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB39301
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
YCQKWLWTCDSERKCCEDMVCRLWCKKRL
Physicochemical Analysis
C160H250N46O42S7
ANGHIFP
C
3714.45
8.31
7
4
9
+3
3.97
-0.676
50.34
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
18365
494.42
10
Residue Composition
number
0
A
3
R
0
N
2
D
6
C
2
E
1
Q
0
G
0
H
0
I
3
L
4
K
1
M
0
F
0
P
1
S
1
T
3
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 2 C: 6 E: 2 Q: 1 G: 0 H: 0 I: 0 L: 3 K: 4 M: 1 F: 0 P: 0 S: 1 T: 1 W: 3 Y: 1 V: 1
Chemical Descriptors
29
C160H250N46O42S7
3714.45
8.31
+3
3.97
-0.676
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibits the voltage-gated sodium channels Nav1.1/SCN1A (IC(50)=360 nM), Nav1.2/SCN2A (IC(50)=600 nM), Nav1.3/SCN3A (IC(50)=1280), Nav1.4/SCN4A (IC(50)=330 nM), Nav1.6/SCN8A (IC(50)=1200 nM), Nav1.7/SCN9A (IC(50)=1-40 nM), and voltage-gated potassium channels Kv11.1/KCNH2 (IC(50)=4.8 uM) (PubMed:19955179, PubMed:30661758, PubMed:31234412). Induces analgesia in mammals (Ref.1). This analgesia is mediated by a non-opioid receptor related mechanism (Ref.1). {ECO:0000269|PubMed:19955179, ECO:0000269|PubMed:30661758, ECO:0000269|PubMed:31234412, ECO:0000269|Ref.1}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Inhibits the voltage-gated sodium channels Nav1.1/SCN1A (IC(50)=360 nM), Nav1.2/SCN2A (IC(50)=600 nM), Nav1.3/SCN3A (IC(50)=1280), Nav1.4/SCN4A (IC(50)=330 nM), Nav1.6/SCN8A (IC(50)=1200 nM), Nav1.7/SCN9A (IC(50)=1-40 nM), and voltage-gated potassium channels Kv11.1/KCNH2 (IC(50)=4.8 uM) (PubMed:19955179, PubMed:30661758, PubMed:31234412). Induces analgesia in mammals (Ref.1).
Beta-theraphotoxin-Gr1b (Beta-TRTX-Gr1b) (GsAF 1) (GsAf1) (GsAF I) (GsAFI)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 30 (phrixotoxin) family
Beta-theraphotoxin-Gr1b (Beta-TRTX-Gr1b) (GsAF 1) (GsAf1) (GsAF I) (GsAFI)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
spider