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Peptide record

TPDB39299

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB39299
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
YCQKFLWTCDTERKCCEDMVCELWCKLEK
Physicochemical Analysis
C157H241N39O46S7
ANGHIPS
C
3635.29
4.84
5
6
9
-1
7.12
-0.476
50.34
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
12865
353.89
10
Residue Composition
number
0
A
1
R
0
N
2
D
6
C
4
E
1
Q
0
G
0
H
0
I
3
L
4
K
1
M
1
F
0
P
0
S
2
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 2 C: 6 E: 4 Q: 1 G: 0 H: 0 I: 0 L: 3 K: 4 M: 1 F: 1 P: 0 S: 0 T: 2 W: 2 Y: 1 V: 1
Chemical Descriptors
29
C157H241N39O46S7
3635.29
4.84
-1
7.12
-0.476
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Insect-selective neurotoxin that potently blocks insect calcium-activated potassium (BKCa) channels (Slo-type) in cockroach dorsal unpaired median (DUM) neurons (IC(50)=3.7 nM) (PubMed:21447641). This occurs in the absence of any shifts in the voltage dependence of activation (PubMed:21447641). At high concentrations (330 nM), it partially inhibits cockroach delayed-rectifier potassium channels (Kv) currents (PubMed:21447641). May interact with the turret and/or loop region of the external entrance to the channel and does not project deeply into the pore of the channel (Probable). In vivo, does not show toxicity in mice after intracerebroventricular injection of up to 25 pmol/g (1.8 ug/20 g mouse) (PubMed:21447641). {ECO:0000269|PubMed:21447641, ECO:0000305|PubMed:21447641}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Eucratoscelus constrictus (African red-rump baboon spider) (Harpactira constricta)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Insect-selective neurotoxin that potently blocks insect calcium-activated potassium (BKCa) channels (Slo-type) in cockroach dorsal unpaired median (DUM) neurons (IC(50)=3.7 nM) (PubMed:21447641). This occurs in the absence of any shifts in the voltage dependence of activation (PubMed:21447641).
Lambda-theraphotoxin-Ec2a (Lambda-TRTX-Ec2a) (Kappa-theraphotoxin-Ec2a) (Kappa-TRTX-Ec2a)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:21447641}.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Neurotoxin 30 (phrixotoxin) family
Lambda-theraphotoxin-Ec2a (Lambda-TRTX-Ec2a) (Kappa-theraphotoxin-Ec2a) (Kappa-TRTX-Ec2a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:21447641}.
spider