Back to search

Peptide record

TPDB39298

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB39298
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
YCQFKMWTCDSERKCCEDMVCRLWCKLNL
Physicochemical Analysis
C155H240N42O43S8
AGHIP
C
3636.35
7.62
5
4
10
+1
3.08
-0.314
50.34
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
12865
353.79
11
Residue Composition
number
0
A
2
R
1
N
2
D
6
C
2
E
1
Q
0
G
0
H
0
I
3
L
3
K
2
M
1
F
0
P
1
S
1
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 2 C: 6 E: 2 Q: 1 G: 0 H: 0 I: 0 L: 3 K: 3 M: 2 F: 1 P: 0 S: 1 T: 1 W: 2 Y: 1 V: 1
Chemical Descriptors
29
C155H240N42O43S8
3636.35
7.62
+1
3.08
-0.314
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Both insecticidal and vertebrate neurotoxin that potently blocks insect calcium-activated potassium (BKCa) channels (Slo-type) in cockroach dorsal unpaired median (DUM) neurons (IC(50)=24.6 nM) (PubMed:21447641). This occurs in the absence of any shifts in the voltage dependence of activation (PubMed:21447641). May interact with the turret and/or loop region of the external entrance to the channel and does not project deeply into the pore of the channel (Probable). Also shows toxicity to mice by introcerebroventicular injection (PubMed:21447641). {ECO:0000269|PubMed:21447641, ECO:0000305|PubMed:21447641}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Eucratoscelus constrictus (African red-rump baboon spider) (Harpactira constricta)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Both insecticidal and vertebrate neurotoxin that potently blocks insect calcium-activated potassium (BKCa) channels (Slo-type) in cockroach dorsal unpaired median (DUM) neurons (IC(50)=24.6 nM) (PubMed:21447641). This occurs in the absence of any shifts in the voltage dependence of activation (PubMed:21447641).
Lambda-theraphotoxin-Ec2c (Lambda-TRTX-Ec2c) (Kappa-theraphotoxin-Ec2c) (Kappa-TRTX-Ec2c)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:21447641}.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Neurotoxin 30 (phrixotoxin) family
Lambda-theraphotoxin-Ec2c (Lambda-TRTX-Ec2c) (Kappa-theraphotoxin-Ec2c) (Kappa-TRTX-Ec2c)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:21447641}.
spider