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Peptide record

TPDB39297

Neurotoxin Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB39297
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
YCQEFLWTCDEERKCCGDMVCRLWCKKRL
Physicochemical Analysis
C156H242N44O43S7
ANHIPS
C
3646.33
7.62
6
5
9
+1
5.60
-0.521
50.34
Mammalian: 2.8 hour Yeast: 10 min E.coli: 2 min
12865
352.82
9
Residue Composition
number
0
A
3
R
0
N
2
D
6
C
3
E
1
Q
1
G
0
H
0
I
3
L
3
K
1
M
1
F
0
P
0
S
1
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 2 C: 6 E: 3 Q: 1 G: 1 H: 0 I: 0 L: 3 K: 3 M: 1 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 1
Chemical Descriptors
29
C156H242N44O43S7
3646.33
7.62
+1
5.60
-0.521
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Spider venom neurotoxin that blocks voltage-gated sodium channel Nav1.3/SCN3A in human (IC(50)=1 uM) and rat (IC(50)=1 uM). Partially inhibits human Kv11.1/KCNH2/ERG (40% at 10 uM). {ECO:0000269|Ref.1}.

Target

voltage-gated sodium channel (Nav) voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Pterinochilus murinus (Mombasa golden starburst baboon spider)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Spider venom neurotoxin that blocks voltage-gated sodium channel Nav1.3/SCN3A in human (IC(50)=1 uM) and rat (IC(50)=1 uM). Partially inhibits human Kv11.1/KCNH2/ERG (40% at 10 uM)..
Beta/kappa-theraphotoxin-Pmu2a (Beta/kappa-TRTX-Pmu2a) (Beta/kappa-theraphotoxin-Pm2a) (Beta/kappa-TRTX-Pm2a) (Pterinotoxin-2)
spider
Neurotoxin 30 (phrixotoxin) family
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Neurotoxin 30 (phrixotoxin) family
Beta/kappa-theraphotoxin-Pmu2a (Beta/kappa-TRTX-Pmu2a) (Beta/kappa-theraphotoxin-Pm2a) (Beta/kappa-TRTX-Pm2a) (Pterinotoxin-2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider