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Peptide record

TPDB39248

Toxicity modified_plain modified
10 amino acids
Basic Information
3D PDB MODEL
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TPDB39248
Toxicity
Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 10-aa modified toxicity peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
XGLXGGLXGI
Physicochemical Analysis
C26H47N7O8
ARNDCEQHKMFPSTWYV
G
585.70
6.02
0
0
3
-0
-1.39
1.050
117.00
Mammalian: Yeast: E.coli:
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
1
I
2
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 1 L: 2 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C26H47N7O8
585.70
6.02
-0
-1.39
1.050
Evidence Records 9 records
Evidence 1 Activity

Activity

2% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
2% Hemolysis | 15 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Trichogin GA IV: an antibacterial and protease-resistant peptide. | J Pept Sci | 2009
Evidence 2 Activity

Activity

25% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
25% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The peculiar N- and (-termini of trichogin GA IV are needed for membrane interaction and human cell death induction at doses lacking antibiotic activity. | Biochim Biophys Acta | 2015
Evidence 3 Activity

Activity

50% Cell death
Toxicity
4 µg/mL
Cytotoxic
50% Cell death | 4 | µg/mL | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. | Sci Rep | 2016
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The peculiar N- and (-termini of trichogin GA IV are needed for membrane interaction and human cell death induction at doses lacking antibiotic activity. | Biochim Biophys Acta | 2015
Evidence 5 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human lymphocytes

Target

Human lymphocytes

Source & Reference

NA
DBAASP
The peculiar N- and (-termini of trichogin GA IV are needed for membrane interaction and human cell death induction at doses lacking antibiotic activity. | Biochim Biophys Acta | 2015
Evidence 6 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human monocytes

Target

Human monocytes

Source & Reference

NA
DBAASP
The peculiar N- and (-termini of trichogin GA IV are needed for membrane interaction and human cell death induction at doses lacking antibiotic activity. | Biochim Biophys Acta | 2015
Evidence 7 Activity

Activity

50% Cell death
Toxicity
5 µM
Cytotoxic
50% Cell death | 5 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. | Sci Rep | 2016
Evidence 8 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
The rational search for selective anticancer derivatives of the peptide Trichogin GA IV: a multi-technique biophysical approach. | Sci Rep | 2016
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2015 Jan 1848(1 Pt A):134-44.