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Peptide record

TPDB39243

Antifungal Toxicity modified_plain modified
1 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB39243
Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
CAFPdb Peptipedia
modified_plain
Yes
A 1-aa modified multi-activity (Antifungal and Toxicity) peptide sequence curated from CAFPdb and Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
X
Physicochemical Analysis
ARNDCEQGHILKMFPSTWYV
18.02
6.02
0
0
0
-0
0.00
0.000
0.00
Mammalian: Yeast: E.coli:
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
1
18.02
6.02
-0
0.00
0.000
Evidence Records 48 records
Evidence 1 Activity

Activity

IC50
Toxicity
17 µg/mL
Cytotoxic
IC50 | 17 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Unusual enniatins produced by the insect pathogenic fungus Verticillium hemipterigenum: isolation and studies on precursor-directed biosynthesis | Tetrahedron | 2003
Evidence 2 Activity

Activity

IC50
Toxicity
18 µg/mL
Cytotoxic
IC50 | 18 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Unusual enniatins produced by the insect pathogenic fungus Verticillium hemipterigenum: isolation and studies on precursor-directed biosynthesis | Tetrahedron | 2003
Evidence 3 Activity

Activity

IC50
Toxicity
38 µg/mL
Cytotoxic
IC50 | 38 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Unusual enniatins produced by the insect pathogenic fungus Verticillium hemipterigenum: isolation and studies on precursor-directed biosynthesis | Tetrahedron | 2003
Evidence 4 Activity

Activity

IC50
Toxicity
45 µg/mL
Cytotoxic
IC50 | 45 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Unusual enniatins produced by the insect pathogenic fungus Verticillium hemipterigenum: isolation and studies on precursor-directed biosynthesis | Tetrahedron | 2003
Evidence 5 Activity

Activity

IC50
Toxicity
1.4 µg/mL
Cytotoxic
IC50 | 1.4 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Unusual enniatins produced by the insect pathogenic fungus Verticillium hemipterigenum: isolation and studies on precursor-directed biosynthesis | Tetrahedron | 2003
Evidence 6 Activity

Activity

IC50
Toxicity
400 µM
Cytotoxic
IC50 | 400 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. | J Med Chem | 2003
Evidence 7 Activity

Activity

IC50
Toxicity
240 µM
Cytotoxic
IC50 | 240 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. | J Med Chem | 2003
Evidence 8 Activity

Activity

IC50
Toxicity
4 µM
Cytotoxic
IC50 | 4 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. | J Med Chem | 2003
Evidence 9 Activity

Activity

IC50
Toxicity
35 µM
Cytotoxic
IC50 | 35 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. | J Med Chem | 2003
Evidence 10 Activity

Activity

IC50
Toxicity
6.3 µM
Cytotoxic
IC50 | 6.3 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. | J Med Chem | 2003
Evidence 11 Activity

Activity

IC50
Toxicity
25 µM
Cytotoxic
IC50 | 25 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. | J Med Chem | 2003
Evidence 12 Activity

Activity

IC50
Toxicity
21 µM
Cytotoxic
IC50 | 21 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. | J Med Chem | 2003
Evidence 13 Activity

Activity

IC50
Toxicity
97.5 µM
Cytotoxic
IC50 | 97.5 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. | J Med Chem | 2003
Evidence 14 Activity

Activity

90% Cytotoxicity
Toxicity
2.5 µM
Cytotoxic
90% Cytotoxicity | 2.5 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Synthesis, Antimicrobial Activity, and Tyrosinase Inhibition by Multifunctional 3,4-Dihydroxy-Phenyl Peptidomimetics | Int J Mol Sci | 2025
Evidence 15 Activity

Activity

95% Cytotoxicity
Toxicity
3.5 µM
Cytotoxic
95% Cytotoxicity | 3.5 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Synthesis, Antimicrobial Activity, and Tyrosinase Inhibition by Multifunctional 3,4-Dihydroxy-Phenyl Peptidomimetics | Int J Mol Sci | 2025
Evidence 16 Activity

Activity

80% Cytotoxicity
Toxicity
2.5 µM
Cytotoxic
80% Cytotoxicity | 2.5 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Synthesis, Antimicrobial Activity, and Tyrosinase Inhibition by Multifunctional 3,4-Dihydroxy-Phenyl Peptidomimetics | Int J Mol Sci | 2025
Evidence 17 Activity

Activity

8.4±1.4% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
8.4±1.4% Hemolysis | 512 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Dilipid Ultrashort Tetrabasic Peptidomimetics Potentiate Novobiocin and Rifampicin Against Multidrug-Resistant Gram-Negative Bacteria. | ACS Infect Dis | 2020
Evidence 18 Activity

Activity

5.4±1.5 % Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
5.4±1.5 % Hemolysis | 512 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Dilipid Ultrashort Tetrabasic Peptidomimetics Potentiate Novobiocin and Rifampicin Against Multidrug-Resistant Gram-Negative Bacteria. | ACS Infect Dis | 2020
Evidence 19 Activity

Activity

6.9±1.5% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
6.9±1.5% Hemolysis | 16 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Dilipid Ultrashort Tetrabasic Peptidomimetics Potentiate Novobiocin and Rifampicin Against Multidrug-Resistant Gram-Negative Bacteria. | ACS Infect Dis | 2020
Evidence 20 Activity

Activity

20.1±14.0% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
20.1±14.0% Hemolysis | 32 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Dilipid Ultrashort Tetrabasic Peptidomimetics Potentiate Novobiocin and Rifampicin Against Multidrug-Resistant Gram-Negative Bacteria. | ACS Infect Dis | 2020
Evidence 21 Activity

Activity

34.3±7.1% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
34.3±7.1% Hemolysis | 128 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Dilipid Ultrashort Tetrabasic Peptidomimetics Potentiate Novobiocin and Rifampicin Against Multidrug-Resistant Gram-Negative Bacteria. | ACS Infect Dis | 2020
Evidence 22 Activity

Activity

50% Hemolysis
Toxicity
40.63 µM
Hemolytic Cytotoxic
50% Hemolysis | 40.63 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Evidence 23 Activity

Activity

<10% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
<10% Hemolysis | 200 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 24 Activity

Activity

30% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
30% Hemolysis | 50 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 25 Activity

Activity

50% Hemolysis
Toxicity
40.64 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 40.64 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 26 Activity

Activity

50% Hemolysis
Toxicity
52.54 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 52.54 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 27 Activity

Activity

50% Hemolysis
Toxicity
89.91 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 89.91 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 28 Activity

Activity

15% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
15% Hemolysis | 50 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 29 Activity

Activity

12% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
12% Hemolysis | 50 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 30 Activity

Activity

<10% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
<10% Hemolysis | 50 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 31 Activity

Activity

50% Hemolysis
Toxicity
189.9 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 189.9 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 32 Activity

Activity

50% Hemolysis
Toxicity
109 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 109 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 33 Activity

Activity

50% Hemolysis
Toxicity
371.3 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 371.3 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 34 Activity

Activity

50% Hemolysis
Toxicity
344.2 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 344.2 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 35 Activity

Activity

<10% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
<10% Hemolysis | 100 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Discovery of lipidated cysteine-based amphiphiles as bioinspired antimicrobial peptidomimetics against drug-resistant bacteria | Eur J Med Chem | 2025
Evidence 36 Activity

Activity

5% Hemolysis
Toxicity
37-51 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 37-51 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Discovery of adamantane-containing small-molecule peptidomimetics with membrane-disrupting activity for combating drug-resistant Bacteria | Bioorg Chem | 2025
Evidence 37 Activity

Activity

5% Hemolysis
Toxicity
26-37 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 26-37 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Discovery of adamantane-containing small-molecule peptidomimetics with membrane-disrupting activity for combating drug-resistant Bacteria | Bioorg Chem | 2025
Evidence 38 Activity

Activity

5% Hemolysis
Toxicity
38-40 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 38-40 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Discovery of adamantane-containing small-molecule peptidomimetics with membrane-disrupting activity for combating drug-resistant Bacteria | Bioorg Chem | 2025
Evidence 39 Activity

Activity

5% Hemolysis
Toxicity
56-87 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 56-87 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Discovery of adamantane-containing small-molecule peptidomimetics with membrane-disrupting activity for combating drug-resistant Bacteria | Bioorg Chem | 2025
Evidence 40 Activity

Activity

97% Cytotoxicity
Toxicity
3.5 µM
Cytotoxic
97% Cytotoxicity | 3.5 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Synthesis, Antimicrobial Activity, and Tyrosinase Inhibition by Multifunctional 3,4-Dihydroxy-Phenyl Peptidomimetics | Int J Mol Sci | 2025
Evidence 41 Activity

Activity

5% Cytotoxicity
Toxicity
0.5 µM
Cytotoxic
5% Cytotoxicity | 0.5 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Synthesis, Antimicrobial Activity, and Tyrosinase Inhibition by Multifunctional 3,4-Dihydroxy-Phenyl Peptidomimetics | Int J Mol Sci | 2025
Evidence 42 Activity

Activity

88% Cytotoxicity
Toxicity
2.5 µM
Cytotoxic
88% Cytotoxicity | 2.5 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Evidence 43 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Synthesis, Antimicrobial Activity, and Tyrosinase Inhibition by Multifunctional 3,4-Dihydroxy-Phenyl Peptidomimetics | Int J Mol Sci | 2025
Evidence 44 Activity

Activity

95% Cytotoxicity
Toxicity
3.5 µM
Cytotoxic
95% Cytotoxicity | 3.5 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Evidence 45 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Evidence 46 Activity

Activity

8% Cytotoxicity
Toxicity
0.5 µM
Cytotoxic
8% Cytotoxicity | 0.5 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Synthesis, Antimicrobial Activity, and Tyrosinase Inhibition by Multifunctional 3,4-Dihydroxy-Phenyl Peptidomimetics | Int J Mol Sci | 2025
Evidence 47 Activity

Activity

88% Cytotoxicity
Toxicity
2.5 µM
Cytotoxic
88% Cytotoxicity | 2.5 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Synthesis, Antimicrobial Activity, and Tyrosinase Inhibition by Multifunctional 3,4-Dihydroxy-Phenyl Peptidomimetics | Int J Mol Sci | 2025
Evidence 48 Activity

Activity

80% Cytotoxicity
Toxicity
2.5 µM
Cytotoxic
80% Cytotoxicity | 2.5 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Synthesis, Antimicrobial Activity, and Tyrosinase Inhibition by Multifunctional 3,4-Dihydroxy-Phenyl Peptidomimetics | Int J Mol Sci | 2025