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Peptide record

TPDB39195

Neurotoxin Toxicity standard
60 amino acids
Basic Information
3D PDB MODEL
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TPDB39195
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 60-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
WQPPWYCKEPVRIGSCKKQFSSFYFKWTAKKCLPFLFSGCGGNANRFQTIGECRKKCLGK
Physicochemical Analysis
C321H482N86O78S6
DHM
K
6986.25
10.06
12
2
19
+10
2.40
-0.530
40.67
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
19855
284.20
19
Residue Composition
number
2
A
3
R
2
N
0
D
6
C
2
E
3
Q
6
G
0
H
2
I
3
L
9
K
0
M
6
F
4
P
4
S
2
T
3
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 2 D: 0 C: 6 E: 2 Q: 3 G: 6 H: 0 I: 2 L: 3 K: 9 M: 0 F: 6 P: 4 S: 4 T: 2 W: 3 Y: 2 V: 1
Chemical Descriptors
60
C321H482N86O78S6
6986.25
10.06
+10
2.40
-0.530
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Potent blocker of high-voltage-activated calcium ion channels in the nanomolar range, particularly the L-type channels in cerebellar granule cells. The sensitivity of L-, N- and P-type channels to CAC is tissue and species-dependent. Blocks the L-type current of cardiac cells, depressing cardiac contractility.

Target

voltage-gated calcium channel (Cav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Potent blocker of high-voltage-activated calcium ion channels in the nanomolar range, particularly the L-type channels in cerebellar granule cells. The sensitivity of L-, N- and P-type channels to CAC is tissue and species-dependent.
Kunitz-type serine protease inhibitor homolog calcicludine (CAC) (L-type calcium channel blocker)
snake
Venom Kunitz-type family
Evidence at protein level
3D-structure Calcium channel impairing toxin Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
3D-structure Calcium channel impairing toxin Cardiotoxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Secreted Toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin
Evidence at protein level
Venom Kunitz-type family
Kunitz-type serine protease inhibitor homolog calcicludine (CAC) (L-type calcium channel blocker)
TISSUE SPECIFICITY: Expressed by the venom gland.
snake