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Peptide record

TPDB39163

KALA PTD2 (KALA) Cell-penetrating Peptides Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB39163
KALA PTD2 (KALA)
Cell-penetrating Peptides Hemolysis Toxicity
Toxicity and safety peptides Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP HemoPI Hemolytic2
standard
No
A 30-aa standard natural multi-activity (Cell-penetrating Peptides, Hemolysis, and Toxicity) peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Sequence
WEAKLAKALAKALAKHLAKALAKALKACEA
Physicochemical Analysis
C144H248N40O35S1
RNDQGIMFPSTYV
A
3131.86
10.42
8
2
19
+5
4.44
0.283
118.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
5500
175.61
1
Residue Composition
number
12
A
0
R
0
N
0
D
1
C
2
E
0
Q
0
G
1
H
0
I
6
L
7
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 12 R: 0 N: 0 D: 0 C: 1 E: 2 Q: 0 G: 0 H: 1 I: 0 L: 6 K: 7 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
30
C144H248N40O35S1
3131.86
10.42
+5
4.44
0.283
Free
L
Cationic and amphipathic Amphipathic
Linear
Free
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 5 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CV-1, K562, Hep G2, CaCo2 and C2C12 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphipathic
Synthetic
Nucleic acid
Cytoplasm and nucleus
Membrane destabilization
In vitro
CCSTHHHHHHHHHTCCHHHHHHHHTSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HT-29-luc cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Synthetic
PNA
Endocytosis
In vitro
CCSTHHHHHHHHHTCCHHHHHHHHTSSCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Primary Human Foreskin Fibroblasts

Assay & Model

New Zealand White rabbit (7–8 wks old average body weight, 2.0 ± 0.2 kg)
New Zealand White rabbit (7–8 wks old average body weight, 2.0 ± 0.2 kg)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic and amphipathic
Synthetic
CTGF siRNA nanocomplex
Cytosol
In vitro and in vivo
CCSTHHHHHHHHHTCCHHHHHHHHTSSCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

S. Aureus Infected Mac-T Or Hbmec Cell Lines , Ex Vivo Calvaria (Skull Cap)

Assay & Model

Femur injury model (Wistar rats (5 to 6 wks of age))
Femur injury model (Wistar rats (5 to 6 wks of age))

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic and amphipathic
Synthetic
Lysostaphin and LysK
In vitro and in vivo
CCCSSSTTCCCTTTTC
Evidence 5 Hemolysis

Source & Reference

HemoPI
NA
Additional Detail Fields 1 fields
CCSTHHHHHHHHHTCCHHHHHHHHTSSCC CCCSSSTTCCCTTTTC