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Peptide record

TPDB39147

Neurotoxin Toxicity standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB39147
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 27-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
WCKQSGEMCNVLDQNCCDGYCIVFVCT
Physicochemical Analysis
C127H193N33O41S7
ARHP
C
3062.55
3.70
1
3
9
-2
1.51
0.285
61.11
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
7365
240.49
13
Residue Composition
number
0
A
0
R
2
N
2
D
6
C
1
E
2
Q
2
G
0
H
1
I
1
L
1
K
1
M
1
F
0
P
1
S
1
T
1
W
1
Y
3
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 2 C: 6 E: 1 Q: 2 G: 2 H: 0 I: 1 L: 1 K: 1 M: 1 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 3
Chemical Descriptors
27
C127H193N33O41S7
3062.55
3.70
-2
1.51
0.285
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. Induces membrane depolarization and spontaneous repetitive firing of neurons.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus textile (Cloth-of-gold cone)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. Induces membrane depolarization and spontaneous repetitive firing of neurons.
Delta-conotoxin TxVIB (TxIB)
cone snail
Conotoxin O1 superfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:1761058}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Knottin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Conotoxin O1 superfamily
Delta-conotoxin TxVIB (TxIB)
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:1761058}.
cone snail