TPDB

3D PDB MODEL

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TPDB ID TPDB39130

Peptide_Name

ACE inhibitor - VV-hemorphin-5

Activity

ACE inhibitors Antidiabetic Neuropeptide Toxicity

Activity_category_statistics

Cardiometabolic peptides Toxicity and safety peptides Neuroactive peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors, Antidiabetic, Neuropeptide, and other sources) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

VVYPWTQ

FASTA

>TPDB39130|ACE inhibitors;Antidiabetic;Neuropeptide;Toxicity|length=7
VVYPWTQ

Formula C44H61N9O11

Absent Amino Acids ARNDCEGHILKMFS

Common Amino Acids V

Mass 892.02

PI 5.94

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 4

Net Charge -0

Boman Index -1.48

Hydrophobicity 0.057

Aliphatic Index 82.86

Half Life

Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 783.61

Polar Residues 3

number

0

A

0

R

0

N

0

D

0

C

0

E

1

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

1

T

1

W

1

Y

2

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 1 W: 1 Y: 1 V: 2

Length

7

Formula

C44H61N9O11

Mass

892.02

PI

5.94

Net Charge

-0

Boman Index

-1.48

Hydrophobicity

0.057

Chemical_Mass

892.0064

Monoisotopic_Mass

891.4476

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 72.80 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zhao Q., Piot J. M.

Title

Investigation of inhibition angiotensin-converting enzyme (ACE) activity and opioid activity of two hemorphins, LVV-hemorphin-5 and VV-hemorphin-5, isolated from a defined peptic hydrolysate of bovine hemoglobin. Neuropeptides, 31, 147-153, 1997

Year 1997

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC3=C[N]([H])C4=CC=CC=C34)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCC(=O)N)C(=O)O InChI=1S/C44H61N9O11/c1-22(2)35(46)40(59)51-36(23(3)4)41(60)50-32(19-25-12-14-27(55)15-13-25)43(62)53-18-8-11-33(53)39(58)49-31(20-26-21-47-29-10-7-6-9-28(26)29)38(57)52-37(24(5)54)42(61)48-30(44(63)64)16-17-34(45)56/h6-7,9-10,12-15,21-24,30-33,35-37,47,54-55H,8,11,16-20,46H2,1-5H3,(H2,45,56)(H,48,61)(H,49,58)(H,50,60)(H,51,59)(H,52,57)(H,63,64)/t24-,30+,31+,32+,33+,35+,36+,37+/m1/s1 InChIKey: VAEOIFAHJWMTKD-NMUVPRMFSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Opioid peptide according to the BIOPEP-UWM database of bioactive peptides (ID 2571) Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9635)

Number_of_Residues

7