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Peptide record

TPDB39123

Neurotoxin Toxicity standard
45 amino acids
Basic Information
3D PDB MODEL
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TPDB39123
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 45-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
VVLGPASDGRNAAANVKAPDLIALTVRNDCCHNAPCRNNHPGICG
Physicochemical Analysis
C190H313N65O60S4
EQMFWY
A
4596.21
7.86
6
3
16
+1
9.49
-0.111
84.67
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
250
5.44
12
Residue Composition
number
7
A
3
R
6
N
3
D
4
C
0
E
0
Q
4
G
2
H
2
I
3
L
1
K
0
M
0
F
4
P
1
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 7 R: 3 N: 6 D: 3 C: 4 E: 0 Q: 0 G: 4 H: 2 I: 2 L: 3 K: 1 M: 0 F: 0 P: 4 S: 1 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
45
C190H313N65O60S4
4596.21
7.86
+1
9.49
-0.111
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity). Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity). {ECO:0000250|UniProtKB:Q2I2R8}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Conus leopardus (Leopard cone)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity). Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity)..
Alpha-conotoxin-like Lp1.10
cone snail
Conotoxin A superfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17400270}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Amidation Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Conotoxin A superfamily
Alpha-conotoxin-like Lp1.10
TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|PubMed:17400270}.
cone snail