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Peptide record

TPDB38989

Neurotoxin Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB38989
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
VRDAYIAQNYNCVYTCFKNDYCND
Physicochemical Analysis
C125H179N33O41S3
EGHLMPSW
NY
2896.17
4.17
2
3
10
-1
1.77
-0.646
48.75
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
6085
210.10
13
Residue Composition
number
2
A
1
R
4
N
3
D
3
C
0
E
1
Q
0
G
0
H
1
I
0
L
1
K
0
M
1
F
0
P
0
S
1
T
0
W
4
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 4 D: 3 C: 3 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 4 V: 2
Chemical Descriptors
24
C125H179N33O41S3
2896.17
4.17
-1
1.77
-0.646
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission.
Neurotoxin 5 (Neurotoxin V)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:6729843}.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
Neurotoxin 5 (Neurotoxin V)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:6729843}.
scorpion