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Peptide record

TPDB38969

Neurotoxin Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB38969
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
VRDAYIAEDYDCVYHCARDA
Physicochemical Analysis
C100H146N28O34S2
NQGLKMFPSTW
AD
2348.55
4.12
3
5
10
-3
5.37
-0.425
68.50
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
4595
195.65
5
Residue Composition
number
4
A
2
R
0
N
4
D
2
C
1
E
0
Q
0
G
1
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
3
Y
2
V
Amino Acid Distribution
A: 4 R: 2 N: 0 D: 4 C: 2 E: 1 Q: 0 G: 0 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 3 V: 2
Chemical Descriptors
20
C100H146N28O34S2
2348.55
4.12
-3
5.37
-0.425
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Olivierus martensii (Manchurian scorpion) (Mesobuthus martensii)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission.
Neurotoxin BmK 18(2)
scorpion
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
Evidence at protein level
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Ion channel impairing toxin Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily
Neurotoxin BmK 18(2)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion