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Peptide record

TPDB38786

Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB38786
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
VICYRGYNYAQPCPPGENVCFTKTWCDARCYQLGK
Physicochemical Analysis
C179H264N48O50S5
HMS
C
4048.66
8.12
4
2
12
+2
1.50
-0.449
44.57
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
11710
289.23
15
Residue Composition
number
2
A
2
R
2
N
1
D
5
C
1
E
2
Q
3
G
0
H
1
I
1
L
2
K
0
M
1
F
3
P
0
S
2
T
1
W
4
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 1 C: 5 E: 1 Q: 2 G: 3 H: 0 I: 1 L: 1 K: 2 M: 0 F: 1 P: 3 S: 0 T: 2 W: 1 Y: 4 V: 2
Chemical Descriptors
35
C179H264N48O50S5
4048.66
8.12
+2
1.50
-0.449
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds to muscular nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby potently impairing neuromuscular transmission. Pseudo-irreversibly inhibits the nAChR through competitive antagonism. In contrast to other long-chain alpha-neurotoxins, lacks affinity for neuronal alpha-7 nicotinic acetylcholine receptor. {ECO:0000269|PubMed:20950587}.

Target

nicotinic acetylcholine receptor (nAChR) acetylcholine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Acanthophis antarcticus (Common death adder)
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Binds to muscular nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby potently impairing neuromuscular transmission. Pseudo-irreversibly inhibits the nAChR through competitive antagonism.
Alpha-elapitoxin-Aa2a (Alpha-EPTX-Aa2a)
snake
Three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily
Evidence at protein level
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:20950587}.
Additional Detail Fields 7 fields
Acetylcholine receptor inhibiting toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Postsynaptic neurotoxin Secreted Toxin
Neurotoxin Postsynaptic neurotoxin Acetylcholine receptor inhibiting toxin Ion channel impairing toxin
Evidence at protein level
Three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily
Alpha-elapitoxin-Aa2a (Alpha-EPTX-Aa2a)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:20950587}.
snake