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Peptide record

TPDB38759

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB38759
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
VGIPVSCKHSGQCIKPCKDAGMRFGKCMNRKCDCTPK
Physicochemical Analysis
C166H281N53O47S8
ELWY
CK
4027.86
9.27
9
2
8
+6
10.09
-0.473
39.46
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
375
9.31
11
Residue Composition
number
1
A
2
R
1
N
2
D
6
C
0
E
1
Q
4
G
1
H
2
I
0
L
6
K
2
M
1
F
3
P
2
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 2 C: 6 E: 0 Q: 1 G: 4 H: 1 I: 2 L: 0 K: 6 M: 2 F: 1 P: 3 S: 2 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
37
C166H281N53O47S8
4027.86
9.27
+6
10.09
-0.473
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Binds and inhibits potassium channels. Intracerebroventricular injection into mice induces paralyzing symptoms followed by death. Its binding affinity to rat brain synaptosomes is 5-fold lower than this of KTX 1.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Binds and inhibits potassium channels. Intracerebroventricular injection into mice induces paralyzing symptoms followed by death.
Potassium channel toxin alpha-KTx 3.9 (Kaliotoxin-3) (KTX-3)
KTX3
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 8 fields
KTX3
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Potassium channel toxin alpha-KTx 3.9 (Kaliotoxin-3) (KTX-3)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion