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Peptide record

TPDB38758

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB38758
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
VGINVKCKHSGQCLKPCKDAGMRFGKCMNGKCDCTPK
Physicochemical Analysis
C164H278N52O47S8
EWY
K
3986.81
9.25
9
2
8
+6
9.87
-0.516
39.46
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
375
9.41
11
Residue Composition
number
1
A
1
R
2
N
2
D
6
C
0
E
1
Q
5
G
1
H
1
I
1
L
7
K
2
M
1
F
2
P
1
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 2 C: 6 E: 0 Q: 1 G: 5 H: 1 I: 1 L: 1 K: 7 M: 2 F: 1 P: 2 S: 1 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
37
C164H278N52O47S8
3986.81
9.25
+6
9.87
-0.516
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=203.15 pM), Kv1.2/KCNA2 (IC(50)=8.92 nM) from rat and human Kv1.3 KCNA3/KCNA3 (IC(50)=171 pM) potently. At 2 uM, also blocks Shaker IR and has a moderate effect on rat Kv1.6/KCNA6. {ECO:0000269|PubMed:20713119}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=203.15 pM), Kv1.2/KCNA2 (IC(50)=8.92 nM) from rat and human Kv1.3 KCNA3/KCNA3 (IC(50)=171 pM) potently. At 2 uM, also blocks Shaker IR and has a moderate effect on rat Kv1.6/KCNA6..
Potassium channel toxin alpha-KTx 3.13 (MeuKTx)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 03 subfamily
Potassium channel toxin alpha-KTx 3.13 (MeuKTx)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
scorpion