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Peptide record

TPDB38748

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB38748
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
VFINVKCTGSKQCLPACKAAVGKAAGKCMNGKCKCYT
Physicochemical Analysis
C162H275N47O45S7
RDEHW
K
3825.67
9.54
7
0
13
+7
4.00
0.138
58.11
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1865
48.75
13
Residue Composition
number
5
A
0
R
2
N
0
D
6
C
0
E
1
Q
4
G
0
H
1
I
1
L
7
K
1
M
1
F
1
P
1
S
2
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 5 R: 0 N: 2 D: 0 C: 6 E: 0 Q: 1 G: 4 H: 0 I: 1 L: 1 K: 7 M: 1 F: 1 P: 1 S: 1 T: 2 W: 0 Y: 1 V: 3
Chemical Descriptors
37
C162H275N47O45S7
3825.67
9.54
+7
4.00
0.138
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks reversibly Shaker B potassium-channels.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus discrepans (Venezuelan scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Blocks reversibly Shaker B potassium-channels.
Potassium channel toxin alpha-KTx 4.3 (Toxin TdK1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 04 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 04 subfamily
Potassium channel toxin alpha-KTx 4.3 (Toxin TdK1)
TISSUE SPECIFICITY: Expressed by the venom gland.
scorpion