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Peptide record

TPDB38743

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB38743
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
VFINVKCRGSKECLPACKAAVGKAAGKCMNGKCKCYP
Physicochemical Analysis
C165H279N49O44S7
DQHTW
K
3877.75
9.54
8
1
13
+7
6.42
0.011
58.11
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1865
48.09
10
Residue Composition
number
5
A
1
R
2
N
0
D
6
C
1
E
0
Q
4
G
0
H
1
I
1
L
7
K
1
M
1
F
2
P
1
S
0
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 5 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 4 H: 0 I: 1 L: 1 K: 7 M: 1 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 1 V: 3
Chemical Descriptors
37
C165H279N49O44S7
3877.75
9.54
+7
6.42
0.011
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Reversible blocker of both Shaker B potassium channels (high affinity), and Kv1.3/KCNA3 potassium channels of human T lymphocytes (low affinity). {ECO:0000269|PubMed:12445473}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Reversible blocker of both Shaker B potassium channels (high affinity), and Kv1.3/KCNA3 potassium channels of human T lymphocytes (low affinity)..
Potassium channel toxin alpha-KTx 4.4 (Toxin Tc30) (Toxin To30)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 04 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:15025998}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 04 subfamily
Potassium channel toxin alpha-KTx 4.4 (Toxin Tc30) (Toxin To30)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|PubMed:15025998}.
scorpion