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Peptide record

TPDB38742

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB38742
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
VFINAKCRGSPECLPKCKQAIGKAAGKCMNGKCKCYP
Physicochemical Analysis
C168H282N50O45S7
DHTW
K
3946.82
9.54
8
1
11
+7
7.17
-0.281
50.27
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
1865
47.25
11
Residue Composition
number
4
A
1
R
2
N
0
D
6
C
1
E
1
Q
4
G
0
H
2
I
1
L
7
K
1
M
1
F
3
P
1
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 2 D: 0 C: 6 E: 1 Q: 1 G: 4 H: 0 I: 2 L: 1 K: 7 M: 1 F: 1 P: 3 S: 1 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
37
C168H282N50O45S7
3946.82
9.54
+7
7.17
-0.281
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks potassium channels Kv1.2/KCNA2 and Kv1.3/KCNA3 with high affinity (K(d)=1.9 nM and 10.7 nM, respectively). The voltage-dependent steady-state parameters of potassium channel gating are unaffected by the toxin in both channels, but due to the fast association and dissociation kinetics the toxin slows the rate of inactivation of Kv1.3/KCNA3 channels. {ECO:0000269|PubMed:19500613}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Tityus stigmurus (Brazilian scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks potassium channels Kv1.2/KCNA2 and Kv1.3/KCNA3 with high affinity (K(d)=1.9 nM and 10.7 nM, respectively). The voltage-dependent steady-state parameters of potassium channel gating are unaffected by the toxin in both channels, but due to the fast association and dissociation kinetics the toxin slows the rate of inactivation of Kv1.3/KCNA3 channels..
Potassium channel toxin alpha-KTx 4.6 (Tst26)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 04 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:19500613}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 04 subfamily
Potassium channel toxin alpha-KTx 4.6 (Tst26)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:19500613}.
scorpion