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Peptide record

TPDB38729

Neurotoxin Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB38729
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
VGCEECPMHCKGKHAVPTCDDGVCNCNV
Physicochemical Analysis
C116H186N36O40S7
RQILFSWY
C
2949.39
5.21
4
4
6
-2
10.75
-0.171
45.00
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
375
12.71
9
Residue Composition
number
1
A
0
R
2
N
2
D
6
C
2
E
0
Q
3
G
2
H
0
I
0
L
2
K
1
M
0
F
2
P
0
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 2 C: 6 E: 2 Q: 0 G: 3 H: 2 I: 0 L: 0 K: 2 M: 1 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
28
C116H186N36O40S7
2949.39
5.21
-2
10.75
-0.171
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=145 nM), Kv1.2/KCNA2 (IC(50)=2.5 nM), and Kv1.3/KCNA3 (IC(50)=15). Also inhibits calcium-activated potassium channels (KCa/KCNN). {ECO:0000269|PubMed:15165720}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=145 nM), Kv1.2/KCNA2 (IC(50)=2.5 nM), and Kv1.3/KCNA3 (IC(50)=15). Also inhibits calcium-activated potassium channels (KCa/KCNN)..
Potassium channel toxin alpha-KTx 9.5 (Kbot1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 09 subfamily
Evidence at protein level
Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15165720}.
Additional Detail Fields 7 fields
Amidation Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 09 subfamily
Potassium channel toxin alpha-KTx 9.5 (Kbot1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15165720}.
scorpion