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Peptide record

TPDB38728

Neurotoxin Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB38728
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
VGCEECPAHCKGKNAKPTCDDGVCNCNV
Physicochemical Analysis
C113H184N36O41S6
RQILMFSWY
C
2895.28
5.38
4
4
5
-1
11.19
-0.475
38.21
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
375
12.95
10
Residue Composition
number
2
A
0
R
3
N
2
D
6
C
2
E
0
Q
3
G
1
H
0
I
0
L
3
K
0
M
0
F
2
P
0
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 0 N: 3 D: 2 C: 6 E: 2 Q: 0 G: 3 H: 1 I: 0 L: 0 K: 3 M: 0 F: 0 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
28
C113H184N36O41S6
2895.28
5.38
-1
11.19
-0.475
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Calcium channel activator. Rapidly and reversibly activates ryanodine receptor 1 (RYR1). {ECO:0000269|PubMed:15067003}.

Target

voltage-gated calcium channel (Cav) ryanodine receptor

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Hottentotta judaicus (Black scorpion) (Buthotus judaicus)
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Ryanodine-sensitive calcium-release channel impairing toxin
Calcium channel activator. Rapidly and reversibly activates ryanodine receptor 1 (RYR1)..
Potassium channel toxin alpha-KTx 9.6 (BjTx-1)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 09 subfamily
Evidence at protein level
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Ryanodine-sensitive calcium-release channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15067003}.
Additional Detail Fields 7 fields
Calcium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Ryanodine-sensitive calcium-release channel impairing toxin Secreted Toxin
Neurotoxin Calcium channel impairing toxin Ion channel impairing toxin Ryanodine-sensitive calcium-release channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 09 subfamily
Potassium channel toxin alpha-KTx 9.6 (BjTx-1)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:15067003}.
scorpion