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Peptide record

TPDB38634

Neurotoxin Toxicity standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB38634
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia ToxinPred 3.0
standard
No
A 32-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
VACVYRTCDKDCTSRKYRSGKCINNACKCYPY
Physicochemical Analysis
C155H247N47O47S6
EQHLMFW
C
3713.31
8.84
7
2
9
+5
4.98
-0.681
36.56
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
6335
170.60
16
Residue Composition
number
2
A
3
R
2
N
2
D
6
C
0
E
0
Q
1
G
0
H
1
I
0
L
4
K
0
M
0
F
1
P
2
S
2
T
0
W
4
Y
2
V
Amino Acid Distribution
A: 2 R: 3 N: 2 D: 2 C: 6 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 4 M: 0 F: 0 P: 1 S: 2 T: 2 W: 0 Y: 4 V: 2
Chemical Descriptors
32
C155H247N47O47S6
3713.31
8.84
+5
4.98
-0.681
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Blocks Shaker B potassium-channels (Kv1.1/KCNA1 sub-family). {ECO:0000269|PubMed:9688256}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides noxius (Mexican scorpion)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Blocks Shaker B potassium-channels (Kv1.1/KCNA1 sub-family)..
Potassium channel toxin alpha-KTx 10.2 (Cobatoxin-2) (CoTx2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 10 subfamily
Evidence at protein level
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9688256}.
Additional Detail Fields 7 fields
Amidation Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 10 subfamily
Potassium channel toxin alpha-KTx 10.2 (Cobatoxin-2) (CoTx2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:9688256}.
scorpion