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Peptide record

TPDB38633

Neurotoxin Toxicity standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB38633
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 47-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
VACRCESDGPDVRSATFTGTVDLWNCNTGWHKCIATYTAVASCCKKD
Physicochemical Analysis
C214H332N62O70S6
QM
CT
5085.72
6.76
6
5
15
-0
6.39
-0.191
51.91
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
12865
252.96
18
Residue Composition
number
5
A
2
R
2
N
4
D
6
C
1
E
0
Q
3
G
1
H
1
I
1
L
3
K
0
M
1
F
1
P
3
S
6
T
2
W
1
Y
4
V
Amino Acid Distribution
A: 5 R: 2 N: 2 D: 4 C: 6 E: 1 Q: 0 G: 3 H: 1 I: 1 L: 1 K: 3 M: 0 F: 1 P: 1 S: 3 T: 6 W: 2 Y: 1 V: 4
Chemical Descriptors
47
C214H332N62O70S6
5085.72
6.76
-0
6.39
-0.191
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Is potently lethal to crabs, although it showed neither lethal activity in mice nor hemolytic activity. May bind to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction. {ECO:0000269|PubMed:9133708}.

Target

voltage-gated sodium channel (Nav)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Isohalcurias carlgreni (Sea anemone) (Halcurias carlgreni)
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Is potently lethal to crabs, although it showed neither lethal activity in mice nor hemolytic activity. May bind to voltage-gated sodium channels (Nav), thereby delaying their inactivation during signal transduction..
Delta-halcutoxin-Hcg1a (Delta-HCTX-Hcg1a) (Halcurin)
sea anemone
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Additional Detail Fields 6 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Nematocyst Neurotoxin Secreted Toxin Voltage-gated sodium channel impairing toxin
Neurotoxin Ion channel impairing toxin Voltage-gated sodium channel impairing toxin
Evidence at protein level
Sea anemone sodium channel inhibitory toxin family, Type II subfamily
Delta-halcutoxin-Hcg1a (Delta-HCTX-Hcg1a) (Halcurin)
sea anemone