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Peptide record

TPDB38613

Neurotoxin Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB38613
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 37-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TVIDVKCTSPKQCVPACKAAMGTVRAKCMNGKCKCYI
Physicochemical Analysis
C165H286N48O47S8
EHLFW
CK
3950.86
9.22
7
1
13
+6
6.59
0.141
63.24
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1865
47.20
13
Residue Composition
number
4
A
1
R
1
N
1
D
6
C
0
E
1
Q
2
G
0
H
2
I
0
L
6
K
2
M
0
F
2
P
1
S
3
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 1 C: 6 E: 0 Q: 1 G: 2 H: 0 I: 2 L: 0 K: 6 M: 2 F: 0 P: 2 S: 1 T: 3 W: 0 Y: 1 V: 4
Chemical Descriptors
37
C165H286N48O47S8
3950.86
9.22
+6
6.59
0.141
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibitor of voltage-gated potassium channels. {ECO:0000250|UniProtKB:P59847}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Rhopalurus junceus (Caribbean blue scorpion) (Heteroctenus junceus)
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Inhibitor of voltage-gated potassium channels..
Potassium channel toxin alpha-KTx 2.19 (Peptide Rj1m2) (Potassium channel toxin alpha-KTx 2.15)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26169670}.
Additional Detail Fields 7 fields
Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin Voltage-gated potassium channel impairing toxin
Neurotoxin Ion channel impairing toxin Potassium channel impairing toxin Voltage-gated potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.19 (Peptide Rj1m2) (Potassium channel toxin alpha-KTx 2.15)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:26169670}.
scorpion