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Peptide record

TPDB38612

Neurotoxin Toxicity standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB38612
Neurotoxin Toxicity
Toxicity and safety peptides
NTxPred2 Peptipedia
standard
No
A 36-aa standard natural multi-activity (Neurotoxin and Toxicity) peptide sequence curated from NTxPred2 and Peptipedia, with an available 3D structural model.
Sequence
TVIDVKCTSPKQCLPPCKEIYGRHAGAKCMNGKCKC
Physicochemical Analysis
C164H277N49O47S7
FW
CK
3911.72
8.88
8
2
9
+5
9.76
-0.358
54.17
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1865
47.68
12
Residue Composition
number
2
A
1
R
1
N
1
D
6
C
1
E
1
Q
3
G
1
H
2
I
1
L
6
K
1
M
0
F
3
P
1
S
2
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 1 C: 6 E: 1 Q: 1 G: 3 H: 1 I: 2 L: 1 K: 6 M: 1 F: 0 P: 3 S: 1 T: 2 W: 0 Y: 1 V: 2
Chemical Descriptors
36
C164H277N49O47S7
3911.72
8.88
+5
9.76
-0.358
Evidence Records 1 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Inhibitor of voltage-gated potassium channels (Kv). This protein is capable of displacing the binding of radio-labeled noxiustoxin (AC P08815) to rat brain synaptosomes with high affinity (about 100 pM). It is also capable of inhibiting transient potassium-currents (resembling I(A)-type currents), in cultured rat cerebellar granule cells. About 50% of the peak currents are reduced by application of a 1.5 uM solution of this toxin. Is lethal to mice (when less than 100 ug are injected). {ECO:0000269|PubMed:7998956}.

Target

voltage-gated potassium channel (Kv)

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Centruroides limpidus (Mexican scorpion)
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Inhibitor of voltage-gated potassium channels (Kv). This protein is capable of displacing the binding of radio-labeled noxiustoxin (AC P08815) to rat brain synaptosomes with high affinity (about 100 pM).
Potassium channel toxin alpha-KTx 2.7 (C.1.limpidus toxin 2) (CllTx2) (Toxin II.10.9.2)
scorpion
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Evidence at protein level
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:7998956}.
Additional Detail Fields 7 fields
Calcium-activated potassium channel impairing toxin Direct protein sequencing Disulfide bond Ion channel impairing toxin Neurotoxin Potassium channel impairing toxin Secreted Toxin
Neurotoxin Calcium-activated potassium channel impairing toxin Ion channel impairing toxin Potassium channel impairing toxin
Evidence at protein level
Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 02 subfamily
Potassium channel toxin alpha-KTx 2.7 (C.1.limpidus toxin 2) (CllTx2) (Toxin II.10.9.2)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|PubMed:7998956}.
scorpion